Ask The Researcher Osteoarthritis

Free event showcasing ground breaking research into Osteoarthritis with the opportunity for discussion with researchers at Leeds Biomedical Research Centre. Everybody with an interest welcome!

Event: Ask the Researcher

Date and time: 14th September – 12:30-2:30 and  6pm-8pm (buffet lunch/ supper and refreshments provided)

Topic: Osteoarthritis and Stem Cells   Osteoarthritis (OA) is an age-related disease. However, ageing and OA are independent processes. In older individuals, factors related to normal ageing (for example, stem cell exhaustion) converge with OA risk factors (for example, genetic factors or obesity) leading to joint tissue deterioration and painful disease. Osteoarthritis involves damage to both cartilage (smooth elastic joint tissue) and the underlying bone. In older people, continued mechanical forces applied to the joints, which may be exacerbated by obesity, lead to cell death in these tissues. Stem cells supply new healthy cells to these tissues, and are termed mesenchymal stem cells (MSCs). In this talk, Dr Elena Jones will present research which shows that the numbers and function of joint-resident MSCs decline with healthy ageing. Furthermore, in OA tissues MSCs gain additional properties which make new bone thicker, but weaker. This has an impact on the overlaying cartilage that becomes exposed to harsher mechanical forces. We will discuss our strategy to modulate MSCs to slow down their ageing and restore their functionality in OA-damaged joints. Dr Jehan El Jawhari will ask how to improve skeletal tissue repair and explore stem cells, implants, and microenvironment.

Presenters: Dr Elena Jones, Dr Jehan El Jawhari and Professor Dennis McGonagle

Location: NIHR Leeds Biomedical Research Centre (formerly LMBRU), 1st Floor Chapel Allerton Hospital (meeting room and seminar room) For more information please contact Gwyn Cracknell on 0113 3924485 or G.T.Cracknell@leeds.ac.uk